La salud infantil y el ambiente. Exposición a pesticidas de poblaciones vulnerables

Autores/as

DOI:

https://doi.org/10.31698/ped.51022024007

Palabras clave:

exposicion, pesticidas, efectos adversos, niños, embarazo

Resumen

Los pesticidas son un grupo de compuestos químicos que tienen diferentes acciones, insecticidas, fungicidas, herbicidas, rodenticidas. Luego de su aplicación,el proceso de degradacion es lento. Pueden permanecer en el suelo y en las aguas subterráneas, contaminando el agua.

El cambio climático transforma el proceso de degradación de los compuestos químicos, por la alteración de la composición del suelo, produciendo alteraciones en el  ecosistema y la biodiversidad.El impacto de los pesticidas sobre la salud humana es un desafío por el gran potencial de daño que tienen.Desde el año 2004, se introduce en Paraguay las semillas geneticamente modificadas, acompañado de un gran incremento de las areas de cultivo y la utilizacion de pesticidas.Con el objetivo de revisar el estado del conocimiento actual sobre los efectos de estas sustancias quimicas, sobre los diferentes organos y sistemas  en las poblaciones pediatricas y embarazadas, se realizo una revision descriptiva, abarcando las principales base de datos disponibles.Como objetivo secundario, considerando la extension de areas de cultivo en Paraguay, describir  los resutlados de los estudios realizados en el pais.

Los resultados de los estudios revisados muestran asociacion entre afectacion de diferentes organos, sistemas, de estas poblaciones y la exposcion ambiental, de las aguas y  los alimentos. Algunos de estos resultados se replican en los realizados en las zonas de cultivo del pais.

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Aktar W, Sengupta D, Chowdhury A. Impact of pesticides use in agriculture: Their benefits and hazards. Interdiscip Toxicol. 2009;2(1):1-12.

Wu L, Chládková B, Lechtenfeld OJ, Lian S, Schindelka J, Herrmann H, et al. Characteriz-ing chemical transformation of organophosphorus compounds by 13C and 2H stable isotope analysis. Sci Total Environ. 2018;615:20-8. doi: 10.1016/j.scitotenv.2017.09.233

Ou J, Li H, Ou X, Yang Z, Chen M, Liu K, et al. Degradation, adsorption and leaching of phenazine-1-carboxamide in agricultural soils. Ecotoxicol Environ Saf [Internet]. 2020;205:111374. doi: 10.1016/j.ecoenv.2020.111374

Zhang H, Qi L, Wu Y, Musiu EM, Cheng Z, Wang P. Numerical simulation of airflow field from a six-rotor plant protection drone using lattice Boltzmann method. Biosyst Eng. 2020;197:336-51. doi: 10.1016/j.biosystemseng.2020.07.018

Van Steenwyk RA, Siegel JP, Bisabri B, Cabuslay CS, Choi JM, Steggall JW, et al. Spray drift mitigation using opposing synchronized air-blast sprayers. Pest Manag Sci. 2021;77(2):895-905.

Zhu S, Niu L, Aamir M, Zhou Y, Xu C, Liu W. Spatial and seasonal variations in air-soil ex-change, enantiomeric signatures and associated health risks of hexachlorocyclohexanes (HCHs) in a megacity Hangzhou in the Yangtze River Delta region, China. Sci Total Environ. 2017;599-600:264-72. doi: 10.1016/j.scitotenv.2017.04.181

Wang Y, Zhang S, Cui W, Meng X, Tang X. Polycyclic aromatic hydrocarbons and organo-chlorine pesticides in surface water from the Yongding River basin, China: Seasonal distribu-tion, source apportionment, and potential risk assessment. Sci Total Environ [Internet]. 2018;618:419-29. doi: 10.1016/j.scitotenv.2017.11.066

Boedeker W, Watts M, Clausing P, Marquez E. The global distribution of acute uninten-tional pesticide poisoning: estimations based on a systematic review. BMC Public Health. 2020;20(1):1-19.

Nakayama H, Garcete G, Morinigo J, Achinelli M, Olmedo S, Cabral A, et al. Evaluación del impacto económico de la implementación de la soja transgénica en Paraguay, 1994-2014 [Internet]. 2018. [Citado 05 Jun 2024] Disponible en: https://www.conacyt.gov.py/sites/default/files/upload_editores/u294/Triptico_proy_soja_mayo2018.pdf

Cámara Paraguaya de Exportadores y Comercializadores de Cereales y Oleaginosas (CAPECO). Área de siembra, producción y rendimiento [Internet]. [Citado 05 Jul 2024] Dis-ponible en: https://capeco.org.py/area-de-siembra-produccion-y-rendimiento/

Cámara Paraguaya de Exportadores y Comercializadores de Cereales y Oleaginosas (CAPECO). Estudio satelital [Internet]. [Citado 05 Jun 2024]. Disponible en: https://capeco.org.py/soja-satelital-es/c

Servicio Nacional de Calidad y Sanidad Vegetal y de Semillas (SENAVE). Anuario 2007 [Internet]. 2007. [Citado 05 Jun 2024] Disponible en: https://www.senave.gov.py/docs/publicaciones/anuarios/anuario2007.pdf

Servicio Nacional de Calidad y Sanidad Vegetal y de Semillas (SENAVE). Anuario 2020 [Internet]. 2020. [Citado 05 Jun 2024]. Disponible en: https://www.senave.gov.py/docs/publicaciones/informes/ANUARIO%20Estadistico%202020%20sin%20ISBN.pdf

World Health Organization (WHO). Sustainable Development Goals. The 17 goals [Inter-net]. [Citado 05 Jun 2024] Disponible en: https://www.un.org/sustainabledevelopment/sustainable-development-goals/

Pedon de Araujo Cardoso T, Viturino da Silva JW, Kishishita J, Galindo Bedor CN, Ga-lindo Bedor DC, Pereira de Santana D, et al. Pesticide dermal absorption: Case study x in vitro study. Environ Toxicol Pharmacol. 2020;75:103313. doi: 10.1016/j.etap.2019.103313

Borges Ferreira V, Fontes Estrella L, Rodrigues Alves G, Gallistl C, Vetter W, Turon Cos-ta Silva T, et al. Residues of legacy organochlorine pesticides and DDT metabolites in highly consumed fish from the polluted Guanabara Bay, Brazil: Distribution and assessment of hu-man health risk. J Environ Sci Health Part B. 2019;54(12):1094-105. doi: 10.1080/03601234.2019.1654808

Silva HCMP da, Bedor DCG, Cunha AN, Rodrigues HO dos S, Telles DL, Araújo ACP, et al. Ethephon and fosetyl residues in fruits from São Francisco Valley, Brazil. Food Addit Con-tam Part B Surveill. 2020;13(1):16-24. doi: 10.1080/19393210.2019.1675779

de Castro Lima JAM, Labanowski J, Bastos MC, Zanella R, Prestes OD, de Vargas JPR, et al. "Modern agriculture" transfers many pesticides to watercourses: A case study of a rep-resentative rural catchment of southern Brazil. Environ Sci Pollut Res. 2020;27(10):10581-98.

van den Dries MA, Pronk A, Guxens M, Spaan S, Voortman T, Jaddoe VW, et al. Deter-minants of organophosphate pesticide exposure in pregnant women: A population-based co-hort study in the Netherlands. Int J Hyg Environ Health. 2018;221(3):489-501. doi: 10.1016/j.ijheh.2018.01.013

Béranger R, Hardy EM, Binter AC, Charles MA, Zaros C, Apenzeller B, et al. Multiple pesticides in mothers' hair samples and children's measurements at birth: Results from the French national birth cohort (ELFE). Int J Hyg Environ Health. 2020;223(1):22-33. doi: 10.1016/j.ijheh.2019.10.010

One Health Commission. What is One Health [Internet]. 2018. [Citado 05 Jun 2024] Dis-ponible en: https://www.onehealthcommission.org/en/why_one_health/what_is_one_health/

Björvang RD, Gennings C, Lin PI, Hussein G, Kiviranta H, Rantakokko P, et al. Persis-tent organic pollutants, pre-pregnancy use of combined oral contraceptives, age, and time-to-pregnancy in the SELMA cohort. Environ Health. 2020;19(1):1-14.

Rahimi T, Rafati F, Sharifi H, Seyedi F. General and reproductive health outcomes among female greenhouse workers: A comparative study. BMC Womens Health. 2020;20(1):1-7.

Fucic A, Duca R, Galea KS, Maric T, Garcia K, Bloom M, et al. Reproductive health risks associated with occupational and environmental exposure to pesticides. Int J Environ Res Public Health. 2021;18(12):1-13.

Ferramosca A, Lorenzetti S, Di Giacomo M, Murrieri F, Coppola L, Zara V. Herbicides glyphosate and glufosinate ammonium negatively affect human sperm mitochondria respira-tion efficiency. Reprod Toxicol. 2021;99:48-55. doi: 10.1016/j.reprotox.2020.11.011

Isumi Y, O'Dell KA, Zorumski CF. Glyphosate as a direct and indirect activator of pro-inflammatory signaling and cognitive impairment. Neural Regen Res. 2024;19(10):2212-8. doi: 10.4103/1673-5374.391331

van Wendel de Joode B, Penaloza-Castaneda J, Mora AM, Corrales-Vargas A, Eskenazi B, Hoppin JA, et al. Pesticide exposure, birth size, and gestational age in the ISA birth co-hort, Costa Rica. Environ Epidemiol. 2024;8. doi: 10.1097/EE9.0000000000000290

Lin S, Li J, Yan X, Pei L, Shang X. Maternal pesticide exposure and risk of preterm birth: A systematic review and meta-analysis. Environ Int. 2023;178:108043. doi: 10.1016/j.envint.2023.108043

Kalloo G, Wellenius GA, McCandless L, Calafat AM, Sjodin A, Romano ME, et al. Expo-sures to chemical mixtures during pregnancy and neonatal outcomes: The HOME study. En-viron Int. 2020;13:105219. doi: 10.1016/j.envint.2019.105219

Junqueira Buralli R, Freitas Dultra A, Helena Ribeiro H. Respiratory and allergic effects in children exposed to pesticides: A systematic review. Int J Environ Res Public Health. 2020;17(8):2740. doi: 10.3390/ijerph17082740

Islam JY, Hoppin J, Mora AM, Soto-Martinez ME, Cordoba Gamboa L, Penaloza Cas-taneda JE, et al. Respiratory and allergic outcomes among 5-year-old children exposed to pesticides. Thorax. 2023;78(1):41-9. doi: 10.1136/thoraxjnl-2021-218068

Mora AM, Hoppin JA, Córdoba L, Cano JC, Soto-Martínez D, Eskenazi B, et al. Prenatal pesticide exposure and respiratory health outcomes in the first year of life: Results from the Infants' Environmental Health (ISA) study. Int J Hyg Environ Health. 2020;225:113474. doi: 10.1016/j.ijheh.2020.113474

Baïz N, Just J, Chastang J, Forhan A, de Lauzon-Guillain B, Magnier AM, et al. Maternal diet before and during pregnancy and risk of asthma and allergic rhinitis in children. Allergy Asthma Clin Immunol. 2019;14:40. doi: 10.1186/s13223-019-0353-2

Ghozal M, Kadawathagedara M, Delvert R, Adel-Patient K, Tafflet M, Annesi-Maesano I, et al. Prenatal dietary exposure to chemicals and allergy or respiratory diseases in children in the EDEN mother-child cohort. Environ Int. 2023;180:108195. doi: 10.1016/j.envint.2023.108195

Ghozal M, Kadawathagedara M, Delvert R, Divaret-Chauveau A, Raherison C, Varraso R, et al. Prenatal dietary exposure to mixtures of chemicals is associated with allergy or res-piratory diseases in children in the ELFE nationwide cohort. Environ Health. 2024;23(1):5. doi: 10.1186/s12940-023-01046-y

Rehman K, Irshad K, Kamal S. Exposure of environmental contaminants and develop-ment of neurological disorders. Crit Rev Eukaryot Gene Expr. 2021;31(2):35-53. doi: 10.1615/CritRevEukaryotGeneExpr.2021037550

Mora AM, Córdoba L, Cano JC, Hernandez-Bonilla D, Pardo L, Schnaas L, et al. Prena-tal mancozeb exposure, excess manganese, and neurodevelopment at 1 year of age in the Infants' Environmental Health (ISA) Study. Environ Health Perspect. 2018;125(5):055001. doi: 10.1289/EHP1955

Conejo-Bolaños D, Mora AM, Hernandez-Bonilla D, Cano JC, Menezes-Filho JA, Eske-nazi B, et al. Prenatal current-use pesticide exposure and children's neurodevelopment at one year of age in the Infants' Environmental Health (ISA) birth cohort, Costa Rica. Environ Res. 2024;249:118222. doi: 10.1016/j.envres.2024.118222

Wang A, Wan Y, Mahai G, Qian X, Li Y, Xu S, et al. Association of prenatal exposure to organophosphate, pyrethroid and neonicotinoid insecticides with child neurodevelopment at 2 years of age: A prospective cohort study. Environ Health Perspect. 2023;13(10):2212-8. doi: 10.1289/EHP12097

Ntantu Nkinsa PN, Muckle G, Ayotte P, Lanphear BP, Arbuckle TE, Fraser WD, et al. Or-ganophosphate pesticides exposure during fetal development and IQ scores in 3 and 4-year-old Canadian children. Environ Res. 2020;190:110023. doi: 10.1016/j.envres.2020.110023

Giambò F, Teodoro M, Costa C, Fenga C. Toxicology and microbiota: How do pesticides influence gut microbiota? A review. Int J Environ Res Public Health. 2021;18(11):5510. doi: 10.3390/ijerph18115510

Sharma T, Natesh NS, Pothuraju R, Batra SK, Rachagani S. Gut microbiota: A non-target victim of pesticide-induced toxicity. Gut Microbes. 2023;15(1):2187578. doi: 10.1080/19490976.2023.2187578

Iglesias-Vázquez L, Van Ginkel Riba G, Arija V, Canals J. Composition of gut microbiota in children with autism spectrum disorder: A systematic review and meta-analysis. Nutrients. 2020;12(3):792. doi: 10.3390/nu12030792

Walsh L, Hill C, Ross RP. Impact of glyphosate (Roundup) on the composition and func-tionality of the gut microbiome. Gut Microbes. 2023;15(2):2263935. doi: 10.1080/19490976.2023.2263935

Diario Oficial de la Unión Europea. Reglamento de ejecución (UE) 2023/2660 de la co-misión de 28 de noviembre de 2023 [Internet]. 2023. Disponible en: http://data.europa.eu/eli/reg_impl/2023/2660/oj

International Agency for Research on Cancer (IARC). Q&A on Glyphosate. 2016 [Citado 25 Jun 2024];33(March 2015):2015-7. Available from: https://www.iarc.fr/wp-content/uploads/2018/11/QA_Glyphosate.pdf

Feulefack J, Khan A, Forastiere F, Sergi CM. Parental pesticide exposure and childhood brain cancer: A systematic review and meta-analysis confirming the IARC/WHO monographs on some organophosphate insecticides and herbicides. Children. 2021;8(12):1123. doi: 10.3390/children8121123

Cavalier H, Trasande L, Porta M. Exposures to pesticides and risk of cancer: Evaluation of recent epidemiological evidence in humans and paths forward. Int J Cancer. 2023;152(5):879-912. doi: 10.1002/ijc.34133

Louati K, Kolsi F, Kallel R, Gdoura Y, Borni M, Hakim LS, et al. Research of pesticide metabolites in human brain tumor tissues by chemometrics-based gas chromatography-mass spectrometry analysis for a hypothetical correlation between pesticide exposure and risk factor of central nervous system tumors. ACS Omega. 2023;8(32):29812-35. doi: 10.1021/acsomega.3c04592

Karalexi MA, Tagkas CF, Markozannes G, Tseretopoulou X, Hernandez AF, Schuz J, et al. Exposure to pesticides and childhood leukemia risk: A systematic review and meta-analysis. Environ Pollut. 2021;285:117376. doi: 10.1016/j.envpol.2021.117376

Ruth AL, Umer R, Stewart P, Moore LE, Yucel RMA, Taylor Wilson RMA. Maternal and paternal household pesticide exposure during pregnancy and risk of childhood acute lym-phoblastic leukemia. J Occup Environ Med. 2023;65(7):595-604. doi: 10.1097/JOM.0000000000002859

Base Investigaciones Sociales. Gobierno paraguayo aprueba el trigo transgénico [Inter-net]. 2023 [Citado 25 Jun 2024]. Disponible en: https://www.baseis.org.py/gobierno-paraguayo-aprueba-el-trigo-transgenico/

Takano HK, Dayan FE. Glufosinate-ammonium: A review of the current state of knowledge. Pest Manag Sci. 2020;76(11):3911-25.

Hsiao JT, Pan HY, Kung CT, Cheng FJ, Chuang PC. Assessment of glufosinate-containing herbicide exposure: A multi-center retrospective study. Am J Emerg Med [Inter-net]. 2021;50:232-6. doi: 10.1016/j.ajem.2021.08.017

Oummadi A, Menuet A, Méresse S, Laugeray A, Guillemin G, Mortaud S. The herbicides glyphosate and glufosinate and the cyanotoxin β-N-methylamino-l-alanine induce long-term motor disorders following postnatal exposure: The importance of prior asymptomatic mater-nal inflammatory sensitization. Front Neurosci. 2023;17:106432. Doi: 10.3389/fnins.2023.106432

Flores L, Gamarra G, Paredes M. Monitoreo comunitario para la vigilancia de exposición al uso de plaguicidas en Paraguay, Año 2018. Rev. salud publica Parag. 2019;9:9-18. doi: 10.18004/rspp.2019.junio.9-18

Gamarra G, Tullo E, Salinas Z, Flores L, Paredes M, González H, et al. Implementación de herramienta tecnológica (TIC) para la vigilancia de factores ambientales y posibles afec-ciones relacionadas a la exposición por uso de plaguicidas agrícolas en Paraguay. . Rev. sa-lud publica Parag. 2019;9(1):19-32. doi: 10.18004/rspp.2019.junio.19-32

Benítez-Leite S, Macchi ML, Acosta M. Malformaciones congénitas asociadas a agrotó-xicos. Pediatr (Asunción) [Internet]. 2007 [Citado 05 Jun 2024];34(2):111-21. Available from: https://scielo.conicyt.cl/pdf/rcp/v80n4/art10.pdf

Benítez-Leite S, Macchi ML, Fernández V, Franco D, Ferro EA, Mojoli A, et al. Daño ce-lular en una población infantil potencialmente expuesta a pesticidas. Pediatr (Asunción). 2012;83(4):392-3.

Benítez-Leite S, Franco de Diana DM, Avalos DS, Almada Denis M, Coronel Ovelar C. DNA damage induced by exposure to pesticides in children of rural areas in Paraguay. Indian J Med Res. 2019;150:290-6. Doi: 10.4103/ijmr.IJMR_1497_17

Martínez M, Talavera G, Benítez ML, Noguera J, Mesquita M. Factores de riesgo am-bientales y perinatales en pacientes pediátricos con leucemia linfoblástica aguda, de una población hospitalaria. Estudio de caso-control. Pediatría (Asunción). 2022;49(2):67-76. doi: 10.31698/ped.49022022002

Mesquita Ramirez MN, Acevedo MS, Valdez AC, Orzua-De la Fuente WM, Sarubbi OC, Godoy Sanchez LE. Perinatal outcomes and newborn head circumference and birth weight in residents near soybean fields of Alto Paraná, Paraguay. Int J Environ Stud. 2023. doi: 10.1080/00207233.2023.2170644

Mesquita Ramirez MN, Cardozo Sarubbi O, Casartelli Galeano M, Miño Cantero CS, Bordon Giunta LA. Effects of prenatal environmental exposure to pesticides on the neurode-velopment of children in the department of Alto Paraná, Paraguay at 34-36 months of age. Int J Environ Stud. 2024. doi: 10.1080/00207233.2024.2330274

Hafeez F. Paraguay no cumple con las leyes de control de pesticidas, denuncia experto [Internet]. Noticias ONU. 2022 [citado 05 Jul 2024]. Disponible en: https://news.un.org/es/story/2022/10/1516142

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2024-08-31

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Mesquita Ramirez, M. N., & Cabral de Bejarano, M. S. (2024). La salud infantil y el ambiente. Exposición a pesticidas de poblaciones vulnerables. Pediatría (Asunción), 51(2), 115-132. https://doi.org/10.31698/ped.51022024007

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