Daño celular en una población infantil potencialmente expuesta a pesticidas

Autores/as

  • S Benítez-Leite
  • ML Macchi
  • V Fernández
  • D Franco
  • EA Ferro
  • A Mojoli
  • F Cuevas
  • J Alfonso
  • L Sales

Palabras clave:

genotoxicidad, pesticidas, niños, medio ambiente

Resumen

Los pesticidas pueden producir efectos agudos o crónicos en la salud humana. Muchos de ellos pueden provocar daño en el material genético. Esta modificación en la información genética se ha relacionado con un alto riesgo  de padecer cáncer.  El objetivo del presente trabajo es indagar el daño en el material genético de una población infantil expuesta potencialmente a pesticidas en el ambiente. El diseño metodológico fue de tipo observacional y transversal. Participaron en el estudio 48 niños expuestos potencialmente a pesticidas y 46 niños no expuestos.  Se obtuvo muestra de la mucosa bucal  para determinar daño en el material genético a través de la frecuencia de micronúcleos (MN). Se encontró en el grupo expuesto potencialmente a pesticidas un promedio mayor de micronúcleos (5,1±2,9 vs 1,8±2,0; p<0,0001), un promedio mayor de células binucleadas, (3,5±2,7 vs 1,4±1,4;  p<0,0001),  mayor frecuencia de cariorrexis (18,2±18,4 vs 5,8±18,4; p<0,004) y picnosis (24,8± 18,0 vs 17,1±8,3;  p<0,03). El 40% (19/47) de los niños expuestos potencialmente a pesticidas tuvieron un tiempo de exposición de 6 años. Esta investigación aporta evidencias de daño genético en la población expuesta potencialmente a pesticidas en el ambiente.

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Publicado

2017-12-28

Cómo citar

Benítez-Leite, S., Macchi, M., Fernández, V., Franco, D., Ferro, E., Mojoli, A., Cuevas, F., Alfonso, J., & Sales, L. (2017). Daño celular en una población infantil potencialmente expuesta a pesticidas. Pediatría (Asunción), 37(2), 97-106. Recuperado a partir de https://revistaspp.org/index.php/pediatria/article/view/202

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